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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Afucosylated monoclonal antibodies ： ウィキペディア英語版 Afucosylated monoclonal antibodies Afucosylated monoclonal antibodies are monoclonal antibodies engineered so that the oligosaccharides in the Fc region of the antibody do not have any fucose sugar units. When antibodies are afucosylated the effect is to increase antibody-dependent cellular cytotoxicity (ADCC). == Background == Most approved monoclonal antibodies are of the IgG1 isotype, where two N-linked biantennary complex-type oligosaccharides are bound to the Fc region. The Fc region exercises the effector function of ADCC through its interaction with leukocyte receptors of the FcgammaR family. ADCC is important in the efficacy of cancer antibodies, but with many approved cancer antibodies there is less ADCC that could be desired due to nonspecific IgG competing with the drugs for binding to FcγIIIa on natural killer cells. Afucosylated monoclonal antibodies overcome this problem through improved FcγIIIa binding.〔(【引用サイトリンク】title=Non-fucosylated therapeutic antibodies as next-generation therapeutic antibodies. - PubMed - NCBI )〕 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Afucosylated monoclonal antibodies」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.